Theories of autobiographical memory emphasise effortful, generative search processes in memory retrieval. However recent research suggests that memories are often retrieved directly, without effortful search. We investigated whether direct and generative retrieval differed in the characteristics of memories recalled, or only in terms of retrieval latency. Participants recalled autobiographical memories in response to cue words. For each memory, they reported whether it was retrieved directly or generatively, rated its visuo-spatial perspective, and judged its accompanying recollective experience. Our results indicated that (...) direct retrieval was commonly reported and was faster than generative retrieval, replicating recent findings. The characteristics of directly retrieved memories differed from generatively retrieved memories: directly retrieved memories had higher field perspective ratings and lower observer perspective ratings. However, retrieval mode did not influence recollective experience. We discuss our findings in terms of cue generation and content construction, and the implication for reconstructive models of autobiographical memory. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

In the Tractatus Theologico-Politicus (TTP), Spinoza argues that an individual’s natural right extends as far as their power. Subsequently, in the Tractatus Politicus (TP), he offers a revised argument for the same conclusion. Here I offer an account of the reasons for the revision. In both arguments, an individual’s natural right derives from God’s natural right. However, the TTP argument hinges on the claim that each individual is part of the whole of nature (totius naturae), and for this reason inherits (...) part of the natural right of that whole. Using several analogous cases from the Ethics, I show that this form of argument from division is not compatible with Spinoza’s considered metaphysical views. The revised argument, by contrast, avoids the pitfalls of his earlier efforts. It also better reveals the deep roots by which the monistic metaphysics of the Ethics feeds into Spinoza’s conception of natural right. (shrink)

Anne Conway disagrees with substance dualism, the thesis that minds and bodies differ in nature or essence. Instead, she holds that “the distinction between spirit and body is only modal and incremental, not essential and substantial”. Yet several of her arguments against dualism have little force against the Cartesian, since they rely on premises no Cartesian would accept. In this paper, I show that Conway does have at least one powerful objection to substance dualism, drawn from premises that Descartes seems (...) bound to accept. She argues that two substances differ in nature only if they differ in their “original and peculiar” cause ; yet all created substances have the same original and peculiar cause; so, all created substances have the same nature. As I argue, the Cartesian is under a surprising amount of pressure to accept Conway’s argument, since its key premise is motivated by a conception of substance similar to one endorsed by Descartes in his Principles of Philosophy. (shrink)

Anne Conway rejects the view that creatures are essentially members of any natural kind more specific than the kind 'creature'. That is, she rejects essentialism about species membership. This chapter provides an analysis of one of Anne Conway's arguments against such essentialism, which (as I argue) is drawn from metaethical rather than metaphysical premises. In her view, if a creature's species or kind were inscribed in its essence, that essence would constitute a limit on the creature's potential to participate in (...) the divine good. It is this consideration that ultimately leads her to reject essentialism about species membership. The chapter concludes with an examination of some of the metaethical consequences of Conway's view as well as a lesson it can teach us about ideal adviser accounts of the good. (shrink)

Christian miller invites further clarification about the relationship between accountability and autonomy. Whereas embracing accountability to others for one’s responsibilities in those relationships emphasizes relationality, autonomy accents the individual’s own capacities to exhibit agency in enacting one’s decisions. Accordingly, we theorize that relational capacities for empathic concern and perspective-taking are especially important in the virtue of accountability. The capacity for self-regulation may serve both one’s autonomous pursuits and accountability for carrying out one’s responsibilities...

If one cannot establish givens, such as Platonic ideas, or determiners, such as Kantian categories, as a point of departure for philosophical inquiry, then how is philosophical inquiry to proceed in a non-question-begging manner? This, of course, is the familiar problem of grounding philosophical discourse. In this essay, I hope to offer a Zhuangzian solution—that is, a solution derived from analysis of the Zhuangzi 莊子 text—to this perennial philosophical problem. As a result, I hope to give the reader a critical (...) glimpse into a Zhuangzian philosophy without foundations, thereby providing a potential solution to the preceding problem while displaying the continued relevance of the Zhuangzi text. (shrink)

This book addresses a single overriding question in contemporary philosophy: Given that we know from physics, chemistry, and the other hard sciences that the universe consists entirely of mindless, meaningless physical particles in fields of force, and that these are organized into systems, how do we account for the human reality - the reality of mind, meaning, consciousness, intentionality, society, science, aesthetics, morality, and all of social organization including money, property, government, and marriage? The book features a discussion of the (...) problem of the freedom of the will as well as an account of the problems of political philosophy, particularly the notions of power and human rights. Originally written as lectures, the book includes in an appendix questions on the lectures and John Searle's replies. (shrink)

To promote so-called cultural competence in work of direct-care providers and other health professionals among diverse peoples, cross-cultural training is now widely advised. However, in ethically assessing aims and content of CCT, and surrounding issues and concerns, what should guide us? And if we can elaborate satisfactory moral touchstones, what do they imply for healthcare professionals, overarching structures, and bioethicists? Building on prior work, this paper tries to help answer these questions.

Theory choice can be approached in at least four ways. One of these calls for the application of decision theory, and this article endorses this approach. But applying standard forms of decision theory imposes an overly demanding standard of numeric information, supposedly satisfied by point-valued utility and probability functions. To ameliorate this difficulty, a version of decision theory that requires merely comparative utilities and plausibilities is proposed. After a brief summary of this alternative, the article illustrates how comparative decision theory (...) affords a rational reconstruction of decisions made by exemplary scientists in two cases of theory choice: Buffon’s law and the luminiferous ether. It also offers a rational reconstruction of two cases of theory diagnosis: Mendeleev’s anomalies and the Pioneer anomaly. (shrink)

ABSTRACTThe latest draft of UNESCO's proposed Universal Declaration on Bioethics and Human Rights is a major disappointment. The committee of government ‘experts’ that produced it made sure that it would not introduce any new obligations for States, and so the document simply restates existing agreements and lists desirable goals without specifying how they can be achieved. This article focuses on the shortcomings of the document as it would apply to health care. These shortcomings are evident in the document's scope, aims (...) and principles. The conclusion is that if UNESCO still thinks that such a declaration is needed, it should produce either an ethical document addressed to individuals and groups, which would be primarily educational in nature, or a legal document addressed to States, which should not have the word ‘ethics’ in its title. (shrink)

History, more than other subjects, is confronted with the need to understand the nature of social time. Braudel, representing the objectivist approach, argued that there exists a universal objective world-time permeated by diverse tempi and rhythms. Althusser criticized this view by stating that each level within society has its own set of temporal relations. However, Althusser's argument requires not the rejection, but the further understanding of subjectivity and intersubjectivity. In order for his concepts to have meaning, they must be based (...) on the meaningful intersubjective relationships of the participants. There is a gap between the philosophical concept of subjective meaning and historical practice. Four phenomenological ideal types of time&endash;synchronic, diachronic, specific, and eternal&endash;can be used to replace objective history with a "history" of times. (shrink)

Wolfgang Stegmüller, the leading German philosopher of science, considers the status of scientific revolutions the central issue in the field ever since "the famous Popper-Lakatos-Kuhn discussion" of a decade and a half ago, comments on "almost all contributions to this problem", and offers his alternative solutions in a series of papers culminating with, and summarized in, his recent "A Combined Approach to Dynamics of Theories. How To Improve Historical Interpretations of Theory Change By Applying Set Theoretical Structures", published in Gerard (...) Radnitzky and Gunnar Andersson, editors, The Structure and Development of Science, issued in the Boston Studies in the Philosophy of Science series, volume 59, 1979, pp. 151-86. Popper views scientific revolutions as rational and due to empirical refutations, but there are no refutations in science. Lakatos agrees and assumes that research programs are refutable and their replacements to be revolutions, but the same arguments he launches against Popper apply to him; moreover, applying his philosophy to itself makes it collapse anyway . Kuhn's view was interpreted to be one of scientific revolutions as quite irrational and as arbitrary as mob action. Stegmüller presents revolution in another interpretation of Kuhn - as non-rational, as based on hopes and value judgment but not on facts. He thinks there are big and small revolutions. And he uses his own modifications of J. D. Sneed's famous formal analysis of scientific theory to make his point. After presenting a summary of Stegmüller's ideas in our own way, which seems to us a clarification of presentation with no change of content, especially due to our stressing all differences of opinion, we apply Stegmüller's idea to itself, the way Stegmüller has done with the view of Lakatos, and with similar results. (shrink)

The Metaphysical Club, a gathering of intellectuals in the 1870s associated with Harvard, is widely recognized as the crucible where pragmatism, America's distinctively original philosophy, was refined and proclaimed. Louis Menand's bestseller about the group was a dramatic publishing success. However, only three actual members - Oliver Wendell Holmes Jr., Charles S. Peirce, and William James - appear in this book, alongside other thinkers such as John Dewey who were never in the Club. The Real Metaphysical Club tells the (...) full story of how this influential group shifted the course of philosophy in America. In addition to pioneering pragmatism, the group explored radical empiricism and idealism, and formulated personalism and process philosophy, equally important developments. This volume contains thirty-seven important writings dating from 1870 to 1885 by the real members of the Metaphysical Club. The first section centers on pragmatism and science; the second part collects writings of the lawyers; and the third part covers idealist and personalist philosophers. Many of these writings have never been reprinted before, and nothing like this impressive collection has ever been attempted. A general introduction provides a narrative history, and the editors' three introductions to the volume's sections vividly bring to life the intense meetings, sustained debates, and pioneering thought from the Metaphysical Club. (shrink)

A survey of Kant's philosophical writings reveals an ongoing concern with the problem of moral motivation. The problem is expressed thusly: How can a judgment of the understanding provide a motive sufficient to move the will to an action? ;Kant provides one line of argument in his formal writings on moral theory. The feeling of respect that follows from the recognition of the nobility of the universal moral law provides the motivation or incentive. Through this feeling we are aware that (...) we are beings that belong to an intelligible world that is independent of the mechanism of the sensible world. We are made aware of a higher, supersensible vocation and thus the sublimity of our own nature. ;There is another line of argument, however. A survey of Kant's philosophical writings also reveals a connection between the moral and the aesthetic. In the second Critique duty is called sublime; in his lectures on Ethics from the mid-1760's the feeling that results from free moral action is described as beautiful or sublime. In the Observations on the Feeling of the Beautiful and the Sublime the sublime is described as a "finer" feeling that moves us as we see the dignity of our own nature displayed in presentations of virtue. In the Critique of Judgment the feeling of the sublime is an experience that makes us aware of our supersensible vocation. Awareness of our supersensible nature through the feeling of pleasure and displeasure provides additional moral motivation and supports the incentive provided by the cognitive faculty's formulation of the moral law. ;A survey of Kant's philosophical writings and especially the unpublished lectures on Ethics, Logic and Metaphysics reveals a continuity in Kant's thought in terms of the relation between the moral and the aesthetic and in terms of concern with the problem of moral motivation. The third Critique was intended as the "keystone of the critical arch," but Kant apparently was not satisfied. The Opus postumum reveals the unity Kant was seeking: the supersensible and the sensible are united in the human person through the feeling of pleasure and displeasure. (shrink)

In this essay, Brook Ziporyn’s reading of Zhuangzi 莊子 is explicated and broken down into what I take to be its two primary parts: first, Zhuangzi’s epistemological agnosticism and perspectivism, and second, Zhuangzi’s Wild Card. The former presents a unique set of philosophical problems through the specialized terminology of the classical Chinese lexicon, while the latter tries to remedy these problems. I take the first part of Zhuangzi’s position to be compelling and pertinent, while the second part is problematic. Carrying (...) out the project, I focus primarily on Ziporyn’s recent publication, Ironies of Oneness and Difference, as well as his translation of the Zhuangzi chapters that (allegedly —... (shrink)

As Herrera-Ferrá et al. (2023) carefully explain, the contentious legacy of human rights should not prevent the re-crafting of particular ethico-legal responsibilities and obligations focal to the...

Public and private -- Ownership and liberalism -- Applied ethics -- NASSP Book Award: Gerald Cohen.

Modern philosophy—perhaps better described as post-Enlightenment philosophy—began to emerge in the later half of the nineteenth century and continued to gain strength in its opposition to the Enlightenment’s insistence on the central role of reason and rational discourse in philosophy. The recent attacks on reason in the name of this or that ideology or “ism” do not strengthen but rather weaken the foundations of equality for women and minorities established through the use of reason. Philosophers—male and female of all races—may (...) take justifiable pride in having been by rational argument, agents of liberation for women and minorities. This achievement should not be jeopardized by the rejection of rational argument and evidence in the name of any currently fashionable movement. (shrink)

Despite often being condemned for having a paradigmatically unrealistic or dangerous conception of power, Plato expends much effort in constructing his distinctive conception of power. In the wake of Socrates’ trial and execution, Plato writes about conventional, elitist, and radically unethical conceptions of power only to ‘refute’ them on behalf of a favoured conception of power allied with justice. Are his arguments as pathetic or wrong-headed as many theorists make them out to be – from Machiavelli to contemporary political realists, (...) from ‘political’ critics of Plato ranging from Popper to Arendt? And if not, has our understanding of power been impoverished? This question has been surprisingly unasked, and it is one I address by asking Plato and his critics: What are the dialectical moves Plato makes in refuting Socrates’s opponents and constructing his own conception of legitimate power? Exactly how does he interweave his conception of power with a kind of ethics? How does it compare to recent conceptions of political realism and the power-politics/ethics relationship – e.g., after Marx and Foucault? While addressing these questions I also attend to the issue of Plato’s historicity: to what extent do the limits of his language and world affect our reading of Plato and his political critics? Ultimately, I argue that and how Plato’s conception of power and its political dimensions realistically have much to teach us that we have not learned. (shrink)

Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The (...) animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions. (shrink)

This article interprets demokratia and arete as dynamically related terms of political thought in ancient Greek culture, from Homeric times to the end of the classical era. It does so selectively, identifying three stages in which this relationship is developed: from the Homeric to archaic eras; fifth-century Athenian democracy, in which demokratia and arete are posed as complementary terms; and the fourth century era in which philosophers used virtue to critique democracy. Relying mostly on evidence from writers who have become (...) benchmarks in the history of Western political thought, the argument emphasizes the inherently political dimension of arete during this period of ancient Greek culture. Noting different ways in which arete is related to political power in general and democracy in particular, it also illustrates the manner in which arete is neither philosophically pristine nor merely an instrument. (shrink)

This article interprets demokratia and arete as dynamically related terms of political thought in ancient Greek culture, from Homeric times to the end of the classical era. It does so selectively, identifying three stages in which this relationship is developed: from the Homeric to archaic eras; fifth-century Athenian democracy, in which demokratia and arete are posed as complementary terms; and the fourth century era in which philosophers used virtue to critique democracy. Relying mostly on evidence from writers who have become (...) benchmarks in the history of Western political thought, the argument emphasizes the inherently political dimension of arete during this period of ancient Greek culture. Noting different ways in which arete is related to political power in general and democracy in particular, it also illustrates the manner in which arete is neither philosophically pristine nor merely an instrument of practical power. The effect of the research contradicts traditional and recent readings of democracy and virtue as inherently antagonistic. The aim of the article is to identify ancient Greek contributions to understanding the potential, contingencies and dangers of the relationship between democracy and virtue — one which may benefit both democracy and virtue. (shrink)

Citizens, political leaders, and scholars invoke the term 'democracy' to describe present-day states without grasping its roots or prospects in theory or practice. This book clarifies the political discourse about democracy by identifying that its primary focus is human activity, not consent. It points out how democracy is neither self-legitimating nor self-justifying and so requires critical, ethical discourse to address its ongoing problems, such as inequality and exclusion. Wallach pinpoints how democracy has historically depended on notions of goodness to ratify (...) its power. The book analyses pivotal concepts of democratic ethics such as 'virtue', 'representation', 'civil rightness', 'legitimacy', and 'human rights' and looks at them as practical versions of goodness that have adapted democracy to new constellations of power in history. Wallach notes how democratic ethics should never be reduced to power or moral ideals. Historical understanding needs to come first to highlight the potentials and prospects of democratic citizenship. (shrink)

The notion of 'democracy' as found in ancient Athens and the work of ancient Greek political theorists has crucially functioned as a critical, distant mirror for major authors of twentieth-century political thought -- starting importantly with Ernest Barker but continuing along diverse paths in the works of Karl Popper, Leo Strauss, Hannah Arendt in the wake of World War II, as well as for recent theorists of democracy who have read Athenian practices and critical discourses against the grain of contemporary (...) philosophy, politics, and culture. In all of them, images of 'democracy' in ancient Greek political theory operate simultaneously as historical discoveries, theoretical constructions, and rhetorical supplements for critical renditions of the political realm. As such, they evidence the slippery centrality of ideas of democracy in ancient Greek political thought for the necessary, problematic, and divergent efforts of recent political theorists to justify their ideas as historically rooted, philosophically true, and politically relevant. (shrink)

The notion of ‘democracy’ as found in ancient Athens and the work of ancient Greek political theorists has crucially functioned as a critical, distant mirror for major authors of twentieth-century political thought — starting importantly with Ernest Barker but continuing along diverse paths in the works of Karl Popper, Leo Strauss, Hannah Arendt in the wake ofWorld War II, as well as for recent theorists of democracy who have read Athenian practices and critical discourses against the grain of contemporary philosophy, (...) politics, and culture. In all of them, images of ‘democracy’ in ancient Greek political theory operate simultaneously as historical discoveries, theoretical constructions, and rhetorical supplements for critical renditions of the political realm. As such, they evidence the slippery centrality of ideas of democracy in ancient Greek political thought for the necessary, problematic, and divergent efforts of recent political theorists to justify their ideas as historically rooted, philosophically true, and politically relevant. (shrink)

Notably since Thomas Hobbes, canonically with Benjamin Constant, and conventionally amid Nietzschean, Popperian, Straussian, Arendtian, liberal, republican, political, and sociological readings of ancient texts, contemporary scholarship on the ancients often has employed some version of the dichotomous ancient/modern or ancient/contemporary contrast as a template for explaining, understanding, and interpretively appropriating ancient texts and political practices – particularly those of ancient Greek philosophy and democracy. In particular, this has been done to argue for some conception of political ethics and democracy. I (...) argue that this rhetorical trope, often using Athens and Europe/America as synecdoches for antiquity and modernity, has generated narrow and distorted views of ancient texts and political practices, on the one hand, and their contemporary relevance, on the other – views that misinterpret the theoretical significance of historical phenomena and misread the potential lessons of ancient authorities. Instead, texts and practices should be read either with more qualifications or more fully against a historical dynamic of critical philosophy and political power – including its ethical, cultural, institutional, and governing elements – that is not framed by this dichotomy. (shrink)